publications

Zanotti C, Arena S, De Pascale S, Ciaravolo V, Ferracane R, Troise AD, Pontecorvi C, Pacello F, Niespolo C, Gismondi A, Scaloni A and Marra M.

Anion exchange chromatography-based purification of plant-derived nanovesicles from Brassica oleracea L.: molecular profiling and bioactivity in human cells.

Front. Bioeng. Biotechnol. 13:1617478. doi: 10.3389/fbioe.2025.1617478

Russo R, Colantuono A, Di Gaetano S, Capasso D, Tito A, Pedrone E, Pirone L.

Phaseolus coccineus Seed: A Valued Resource for Bioactive Compounds Targeting Health and Tumor Cells.

International Journal of Molecular Sciences 2025, 26, 2189. https://doi.org/10.3390/ijms26052189

Vitale A, De Musis C, Bimonte M, Rubert J, Fogliano V.

In vitro cellular model systems provide a promising alternative to animal experiments for studying the intestine-organ axis.

Critical Reviews in Biotechnology, 1-18 (2025). https://doi.org/10.1080/07388551.2025.2452620

Becchimanzi A., Cacace A., Parziale M., De Leva G., Iacopino S., Jesu G., Di Lelio I., Stillittano V., Caprio E., Pennacchio F.

The salivary gland transcriptome of Varroa destructor reveals suitable targets for RNAi-based mite control.

Insect Molecular Biology 2024; 1-12.

Tito A, Carpi A, Zappelli C, Niespolo C, Morra F, Rando P.A, Pappas A, Fogliano V.

Plantago lanceolata-derived extracellular vesicles: a powerful strategy for skin regeneration.

P. 34, Skin Ageing & Challeneges 2024, Malta (2024, November 5-6), DOI https://doi.org/10.60738/D4GR-8192

Falanga D, Di Lorenzo R, Tito A, Angelillo M and Laneri S.

Exploring the adaptogenic potential of cordyceps sinensis to promote skin longevity.

HPC Today, 6/2024.

Arciello S., Cannata C., Basile F., La Bella E., Abreu A.C., Fernàndez I., Leonardi C., Mauro R.P.

Exhausted plant cell culture media as potential biostimulants to enhance plant growth and nitrogen use efficiency in tomatoes under optimal and reduced nitrogen supply.

Journal of Plant Nutrition and Soil Science, 2024; 1-12.

Tito A, Zappelli C, Falanga D., Angelillo M.

Harnessing the biotechnological power of Jasminum sambac: a clinical inquiry into skin radiance and pigmentation control.

HPC today, 4, 2024. https://tkshpc.h5mag.com/hpc_today_4_2024/skin_care__harnessing_the_biotechnological_power_of_jasminum_sambac_a_clinical_inquiry_into_skin_radiance

Di Lorenzo R, Falanga D., Ricci L., Colantuono A, Greco G., Angelillo M, Nugnes F, Di Serio T, Costa D., Tito A. and Laneri S.

NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity.

International Journal of Molecular Sciences , 2024, 25, 4282. https://doi.org/10.3390/ijms25084282

Tito A. Di Lorenzo R., Cavallo N., Colucci MG, Laneri S., Zhang T and Fogliano V.

Skin rejuvenating properties of a powerful blend of Gardenia jasminoides peptides and flavonoids.

HPC today, 1 2024 https://tkshpc.h5mag.com/hpc_today_1_2024/skin_care__skin_rejuvenating_properties_of_a_powerful_blend_of_gardenia_jasminoides_peptides_and_flavonoids

Gogliettino M, Cocca E, Apone F, Del Prete S, Balestrieri M, Mirino S, Arciello S and Palmieri G.

A new versatile peroxidase with extremophilic traits over-produced in MicroTom cell cultures.

Scientific Reports volume 13, Article number: 15338 (2023). https://doi.org/10.1038/s41598-023-42597-x

Tito A, Tortora A, Falanga D, Colucci MG and Fogliano V.

Identification of a novel rejuvenation marker for the hair follicle ecosystem.

33rd IFSCC Congress, Barcelona, 4-7 September 2023.

Zappelli C, Tito A, Bimonte M, Colantuono A.

Scalp soothing properties of Portulaca oleracea.

Personal Care Magazine, January 2023.

Tito A, Niespolo C, Monti MC, Colucci MG, Fogliano V.

Oenothera biennis cell culture produce lignans activating Piezo1 triggering the Myosin Light Chain Kinase depending pathways.

Biochemical and Biophysical Research Communications, Volume 681, 2023, Pages 36-40, ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2023.09.056

Tortora A, De Lucia A, Tito A, Angelillo M and Fogliano V.

Jasminum Sambac as natural antioxidant booster against skin aging.

International Journal of Cosmetic Science, 45: 1-61 (2023). https://doi.org/10.1111/ics.12921

Zappelli C, Tito A, Angelillo M, Colantuono A, Falanga D, De Lucia A and Fogliano V.

Imperfectly perfect: moisturising and anti-ageing potential of an oil-soluble extract from rejected avocados.

HPC Today vol. 17 (3), 2022.

Gogliettino M, Arciello S, Cillo F, Carluccio AV, Palmieri G, Apone F, Ambrosio RL, Anastasio A, Gratino L, Carola A and Cocca E.

Recombinant expression of archaeal superoxide dismutases in plant cell cultures: A sustainable solution with potential application in the food industry.

Antioxidants 2022, 11, 1731. https://doi.org/10.3390/antiox11091731.

Zappelli C, Tito A, De Lucia A, Carola A, Falanga D, Carotenuto G, Colantuono A, Fogliano V.

Rose Geranium Rebalances IR-, Blue Light- and UV-Altered Skin Biomarkers.

Cosmetics & Toiletries, September 2022.

Ceccacci S, Roger K, Metatla I, Chhuon C, Tighanimine K, Fumagalli S, De Lucia A, Pranke I, Cordier C, Monti MC and Guerrera C.

Promitotic Action of Oenothera biennis on Senescent Human Dermal Fibroblasts.

International Journal of Molecular Sciences 2022, 23, 15153. https://doi.org/10.3390/ijms232315153.

Tito A, Iacopino S, De Lucia A, Arciello S, Carotenuto G, Vitale A, Niespolo C, Tortora A, Zappelli C, Fogliano V.

Innovative 3D skin and plant models to monitor Piezo1- and Piezo2-driven mechanotransduction.

IFSCC Magazine, Volume 25 (5), 2022.

Ceccacci S, De Lucia A, Tortora A, Colantuono A, Carotenuto G, Tito A and Monti MC.

Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging.

Antioxidants 2022, 11, 2409. https://doi.org/10.3390/antiox11122409.

Tortora A, Bimonte M, Tito A, Zappelli C, Apone F.

Soothing Moves: Cannabis sativa Cell Culture Alleviates Inflammation.

Cosmetic & Toiletries, Jan 2021, vol. 136, n. 1, 34-39.

Dini I, Falanga D, Di Lorenzo R, Tito A, Carotenuto G , Zappelli C, Grumetto L , Sacchi A, Laneri S, Apone F.

An Extract from Ficus carica Cell Cultures Works as an Anti-Stress Ingredient for the Skin.

Antioxidants, 2021, 10, 515. https://doi.org/10.3390/antiox10040515.

Tito A, Colantuono A, Pirone L, Pedone E, Intartaglia D, Giamundo G, Conte I, Vitaglione P, Apone F.

Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs.

Front Chem. 2021 Apr 28;9:638187.

Apone F.

Uses and Properties of Bioactive Peptides in Skin Care.

HPC Today, vol. 16 (3), 2021.

Tito A, De Lucia A, Tortora A, Falanga D, Zappelli C, Angelillo M, Ceccaci S, Monti MC, Ausanio G, Di Cicco C, Apone F, Colucci MG.

An hydrosoluble extract from Oenothera biennis cell culture produces skin anti- ageing effects by improving cell mechanical properties.

The proceeding of the 27th IFSCC congress 2021, Mexico.

Ceccacci S, De Lucia A, Tito A, Tortora A, Falanga D, Arciello S, Ausanio G, Di Cicco C, Monti MC and Apone F.

An Oenothera biennia Cell Cultures Extract Endowed with Skin Anti-Ageing Activity Improves Cell Mechanical Properties.

Metabolites 2021, 11, 527. https://doi.org/10.3390/metabo11080527.

Tito A, Zappelli C, Angelillo M, Colucci MG and Apone F.

A New Ingredient from Rosa rugosa Tissue Cultures Delays Skin Aging by Promoting Mitochondrial Functions.

Personal Care Europe 2020, April 131-137.

Tito A, Minale M, Riccio S, Grieco F, Colucci MG and Apone F.

A Triticum vulgare Extract Exhibits Regenerating Activity during the Wound Healing Process.

Clin Cosm & Invest Dermatol 2020, 13: 21-30.

Apone F, Tito A, Arciello S, Carotenuto G and Colucci MG.

Plant Tissue Cultures as Sources of Ingredients for Skin Care Applications.

Annual Plant Reviews 2020, 3: 135-150.

Tito A, Colantuono A, Pirone L, Pedone E, Intartaglia D, Giamundo G, Conte I, Vitaglione P and Apone F.

A Pomegranate Peel Extract as Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 (in vitro): A Promising Source of Novel Antiviral Drugs.

bioRxiv December 2020, https://doi.org/10.1101/2020.12.01.406116.

Tito A, Tortora A, De Lucia A, Zappelli C, Colucci MG and Apone F.

A Peptide Preparation from Scabiosa arvensis Cell Cultures Increases Skin Compactness by Stimulating Collagen XVII and Insulin-like Growth Factor.

The Proceedings of the 26th IFSCC Congress 2020, Yokohama.

Laneri S, Dini I, Tito A, Di Lorenzo R, Bimonte M, Tortora A, Zappelli C, Angelillo M, Bernardi A, Sacchi A, Colucci MG and Apone F.

Plant Cell Culture Extract of Cirsium eriophorum with Skin Pore Refiner Activity by Modulating Sebum Production and Inflammatory Response.

Phytother Res. 2020; 10.1002/ptr.6832. doi: 10.1002/ptr.6832.

Tito A, Barbulova A, Zappelli C, Leone M, Ruvo M, Mercurio FA, Chambery A, Russo R, Colucci MG & Apone F.

The Growth Differentiation Factor 11 is involved in skin fibroblast ageing and is induced by a preparation of peptides and sugars derived from plant cell cultures.

Mol Biotechnol. 2019 Mar;61(3):209-220.

Apone F, Barbulova A, Colucci MG.

Plant and Microalgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics.

Front. In Plant Sci., 12 June 2019 doi: 10.3389/fpls.2019.00756

Palmieri G, Arciello S, Bimonte M, Carola A, Tito A, Gogliettino M, Cocca E, Fusco C, Balestrieri M, Colucci MG, Apone F.

The extraordinary resistance to UV radiations of a manganese Superoxide Dismutase of Deinococcus radiodurans offers promising potentialities in skin care applications.

J Biotechnol. 2019, 302: 101-111.

Bimonte M, Carola A, Barbulova A, Zappelli C, Angelillo M, Cucchiara M, Apone F and Colucci MG.

Aubergine mutes TRPV1 and boosts TRPV-3 and TRPV-4 to reinforce and comfort skin.

Cosmetics & Toiletries 2019, 134, n. 9, 50-61.

Tito A, Carola A, Bertelli G, Rando P, Nohynek L, Oksman-Caldentey KM, Rischer H, Zappelli C, Colucci MG, Apone F.

A Rubus arcticus derived ingredient stimulates immune defence and reduces inflammation in skin cells by promoting microbiota balance.

The Proceedings of the 25th IFSCC Conference 2019, Milan.

Apone F, Zappelli C, Angelillo M & Colucci MG.

Biotechnology research to obtain safe, effective and sustainable ingredients for Cosmetics (in polish).

Chem & Business, 4/2018: 76-81.

D'Antuono I, Carola A, Sena LM, Linsalata V, Cardinali A, Logrieco AF, Colucci MG and Apone F.

Artichoke polyphenols produce skin anti-age effects by improving endothelial cell integrity and functionality.

Molecules 2018, 23, 2729; doi:10.3390/molecules23112729.

De Lucia A, Zappelli C, Angelillo M, Langellotti AL, Fogliano V, Cucchiara M, Colucci MG, Apone F.

A novel biotechnological active ingredient, derived from the microalga Spirulina, increases hydration and reduces osmotic stress in skin cells.

HPC Today, vol. 13(4) July/August 2018.

Bimonte M, Carola A, Tito A, Barbulova A, De Lucia A, Del Piaz F, Apone F & Colucci MG.

Plant cell cultures of Daphne odora produce compounds that help fighting cold stress in the skin.

Cosmetics & Toiletries, 133, n.1, 34-51.

Di Martino O, Tito A, De Lucia A, Cimmino A, Cicotti F, Apone F, Colucci MG and Calabrò V.

Hibiscus syriacus Extract from an Established Cell Culture Stimulates Skin Wound Healing.

BioMed Res Inter, Article ID 7932019, 9 pages, https://doi.org/10.1155/2017/7932019.

Squillaci G, Apone F, Sena LM, Carola A, Tito A, Bimonte M, De Lucia A, Colucci MG, LA Cara F, Morena A.

Chestnut (Castanea sativa Mill.) industrial wastes as a valued bioresource for the production of active ingredients.

Process Biochemistry, http://dx.doi.org/10.1016/j.procbio.2017.09.017.

Sena LM, Zappelli C, Apone F, Barbulova A, Tito A, Leone A, Oliviero T, Ferracane R, Fogliano V, Colucci MG.

Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution.

J Cosmet Dermatol.1-12.

Apone F, Barbulova A, Zappelli C, Colucci MG.

Green biotechnology in cosmetics: using plant cell cultures as sources of active ingredients.

HPC Today, vol. 12 (3), May/June 2017.

Sandomenico A, Severino V, Apone F, De Lucia A, Caporale A, Dotia N, Russo A, Russo R, Rega C, Del Giacco T, Falcigno L, Ruvo M, Chambery A.

Trifluoroacetylated tyrosine-rich D-tetrapeptides have potentantioxidant activity.

Peptides, 89: 50–59.

Zappelli C, Ciccotti F, Tito A, Carola A, De Lucia A, Sena LM, Tortora A, Bimonte M, Cucchiara M, Apone F, Colucci MG.

Perking Up Skin: Green Coffee Promotes Barrier Recovery, Turn Over and Lightening.

Cosmetics & Toiletries, 132, n.1, 24-36.

Zappelli C, Barbulova A, Apone F, Colucci MG.

Effective Active ingredients obtained through Biotechnology.

Cosmetics, 3, 39.

Rogato A, Valkov VT, Alves LM, Apone F, Colucci MG, Chiurazzi M.

Down-regulated Lotus japonicus GCR1 plants exhibit nodulation signalling pathways alteration.

Plant Sci., 247: 71-82.

Bimonte M, De Lucia A, Carola A, Tito A, Buono S, Langellotti AL, Fogliano V, Colucci MG and Apone F.

Galdieria sulphuraria Relieves Oily and Seborrheic Skin By Inhibiting the 5-α Reductase Expression in Skin Cells and Reducing Sebum Production In Vivo.

Trichology and Cosmetology. Volume 1, tissue 1.

Imparato G, Casale C, Scaramella S, UrciuoloF, Bimonte M, Apone F, Colucci MG and Netti PA.

A novel engineered dermis for in vitro photodamage research.

J Tissue Eng Regen Med. 2016 Feb 8

Tito A, Bimonte M, Carola A, De Lucia A, Barbulova A, Tortora A, Colucci MG & Apone F.

An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells.

Int. J. Cosmet. Sci., 2015 May 4. doi: 10.1111/ics.12236.

Barbulova A, Apone F & Colucci MG.

New Trends in Cosmetics: By-Products of Plant Origin and Their Potential Use as Cosmetic Active Ingredients.

Cosmetics, 2, 82-92.

Apone F, Ruggiero A, Tortora A, Tito A, Grimaldi MR, Arciello S, Andrenacci D, Di Lelio I & Colucci MG.

Targeting the diuretic hormone receptor to control the cotton leafworm, Spodoptera littoralis.

Journal of Insect Science, Vol. 14, 87, 1-16.

Bimonte M, Tito A, Carola A, Barbulova A, Hill J, Cucchiara M, Apone F & Colucci MG.

Dolichos cell culture extract for protection against UV damage.

Cosmetics & Toiletries, 129, 46-56.

Barbulova A, Apone F & Colucci MG.

Plant Cell Cultures as Source of Cosmetic Active Ingredients.

Cosmetics, 1, 94-104.

Carola A, Tito A, Bimonte M, Mustilli AC, Cucchiara M, Monoli I, Hill J, Apone F, Colucci MG.

Liposoluble Extracts of Vitis Vinifera Grape Marc and Cell Cultures with Synergistic Anti-ageing Effects.

HPC Today, vol. 7 nr. 3 July/September 2012.